Senior Vice President, TRN Mapping
Charles joined Kronos Bio in 2019 as the Vice President of Biology and was promoted to Senior Vice President of Biology in 2021. Before joining Kronos Bio, Charles was a Pew-Stewart Scholar for Cancer Research, an Assistant Professor in the Department of Molecular and Human Genetics, and the Co-Director of the Therapeutic Innovation Center at Baylor College of Medicine. His prior research studied cancer through the lens of gene control — the way in which genes in the genome are selectively and programmatically turned on and off. He is a leader in the study of the “MYC” transcription factor, the most commonly amplified human oncogene, and helped uncover its role as a general regulator of gene expression. Through his work he has also helped describe super enhancers, control regions of the genome that activate oncogenes. He has helped advance small molecule inhibitors of transcription towards the clinic in multiple cancers as a therapeutic approach to target cancers with altered gene control. Charles received his Ph.D. in Computational and Systems Biology from the Massachusetts Institute of Technology where he trained with Dr. Richard Young and Dr. Christopher Burge. He completed his academic training with Dr. James Bradner at the Dana-Farber Cancer Institute in the chemical biology program.