We have developed a robust clinical and preclinical pipeline through a combination of internal discovery efforts and focused asset acquisition. The following chart summarizes our product pipeline, including our clinical-stage candidates entospletinib, lanraplenib, and KB-0742, as well as our discovery programs and our next anticipated milestones.
Additional programs from mapping and screening the MYC, AR, MYB, IRF4 and other TRNs
We may not be successful in identifying product candidates that can selectively modulate the specific oncogenic TRNs associated with such programs.
Selective SYK Inhibitors
Our lead product candidate, entospletinib, is a selective inhibitor targeting SYK, a critical node in a dysregulated TRN within acute myeloid leukemia (AML) defined by persistent high expression of the transcription factors HOXA9 and MEIS1 (HOX/MEIS). While directly targeting HOX/MEIS has been historically challenging, we believe that inhibiting SYK represents a tractable strategy to collapse the HOX/MEIS TRN by inhibiting phosphorylation of downstream target genes and by disrupting a positive feedback loop that maintains high levels of MEIS1. Through analysis of AML patient sample datasets, we selected the NPM1c mutation as a robust genomic biomarker of HOX/MEIS elevation in AML. The NPM1c mutation is present in approximately 30% of adult patients with AML.
Data from a Phase 1b/2 trial of entospletinib in 53 patients newly diagnosed with AML support the role of SYK as a critical node in HOX/MEIS high AML, with compelling complete response (CR) rates in NPM1c mutated patients and patients with elevated HOX/MEIS expression. Based on these data and following discussions with the U.S. FDA, in 2021 we initiated a registrational Phase 3 trial for entospletinib in patients newly diagnosed with NPM1-mutated AML. This trial will assess measurable residual disease (MRD) negative complete response (CR) as the primary endpoint to support potential accelerated approval of entospletinib for patients who are newly diagnosed with NPM1-mutated AML and eligible for intensive induction chemotherapy.
Our second SYK inhibitor, lanraplenib, is a next-generation SYK inhibitor that has previously been studied as a potential treatment for autoimmune diseases. In preclinical studies, lanraplenib was shown to have anti-leukemic activity against NPM1-mutated and FLT3-mutated AML samples. We are developing lanraplenib for the treatment of patients with relapsed/refractory FLT3-mutated AML and patients newly diagnosed with NPM1-mutated and/or FLT3-mutated AML who are older than 75 years old or are not eligible for intensive induction chemotherapy.
SYK is a critical dependency in HOXA9/MEIS1-high AML
Our second product candidate, KB-0742, was derived from SMM-based discovery. KB-0742 is a selective, orally bioavailable inhibitor of CDK9, a global regulator of transcription and a critical node in the oncogenic TRN resulting from MYC overexpression. MYC is a well-known transcription factor and cancer driver that is dysregulated in a significant proportion of human cancers, often via genomic copy number gain, or amplification. We intend to develop KB-0742 initially for the treatment of MYC-amplified solid tumors in a tumor type-agnostic approach. We have initiated a Phase 1/2 clinical trial and reported interim positive data from the ongoing study in the fourth quarter of 2021.