Careers

Scientist, Translational Development

Location: Cambridge, MA

POSITION

Kronos Bio seeks an experienced research scientist to join our Translation group. This individual will be expected to support translational activities within the laboratory, employing a variety of molecular and cellular techniques to identify and validate both selection and pharmacodynamic biomarkers. Key skills for success include a diverse experimental skill set, a positive and team-centered attitude, a willingness to learn and work collaboratively, and ability to thrive in a fast-paced environment. In this position within the Clinical Development group, the candidate will develop and implement biomarker assays for pre-clinical and clinical stage programs, helping to identify potential MOA, patient stratification, PD, efficacy biomarkers using cutting edge next generation platforms like digital spatial profiling and digital PCR.  The candidate should have proven bench level expertise in establishing and performing a wide range of molecular and protein-based assays. The candidate will also be responsible for guiding and overseeing CROs for multiple projects, including overseeing internally developed assay transfers if required. Keeping the company up to date with the latest tools and platforms for both protein/nucleic acid-based markers will also be the candidate’s responsibility. This position offers the opportunity to contribute to both drug discovery and clinical projects in an innovative and fast-paced team environment with tremendous growth opportunity.

ESSENTIAL FUNCTIONS AND DUTIES

  • Take ownership of complex platforms and drive the initial setup and infrastructure needed to get the platforms up and running
  • Develop, validate and implement biomarker assays
  • Maintain mammalian cell lines and primary human samples in tissue culture
  • Develop, validate, and execute cell-based assays to evaluate resistance mechanisms and combinations
  • Use molecular techniques including nucleic acid extraction, RT-PCR, qPCR/ddPCR, western blot, and MSD to characterize cell lines, primary human samples, preclinical and clinical trial samples
  • Evaluate protein expression in preclinical and clinical trial samples using IF and IHC
  • Work collaboratively with other scientists within our multi-disciplinary Cambridge research team
  • Maintain accurate, well-organized experimental records
  • Organize and present experimental results at regular team meetings
  • Maintain up to date knowledge of advancements in the field including new laboratory techniques/technologies

SKILLS AND EXPERIENCE

  • PhD with 2+ years of industrial/post-doctoral experience
  • Experience with protein and cell-based assays, including IHC, Elisa’s
  • Experience with molecular biology technologies (e.g. NGS, expression profiling) is highly desirable
  • Experience with mammalian cell lines and primary human samples in tissue culture
  • Proven ability to work independently and design experiments, troubleshoot, interpret and report data
  • Highly analytical mind, attention to detail, and organization skills are critical
  • Collaborative and proactive attitude with excellent written and oral communication skills
  • Embodies Kronos values; exhibits high degree of integrity and professionalism when interacting with outside investigators and vendors
  • Entrepreneurial and enjoys working in a fast-paced, creative and resourceful small company environment

To apply for this position, please forward your resume and cover letter to careers@kronosbio.com.